Liposomes and phospholipid/surfactant vesicles
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Liposomes and phospholipid/surfactant vesicles in vitro and in vivo skin application by Maria Elisabeth Mechtilda JoseМЃ van Kuijk-Meuwissen

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Published by University of Leiden in [Leiden .
Written in English


Book details:

Edition Notes

StatementMaria Elisabeth Mechtilda José van Kuijk-Meuwissen.
Classifications
LC ClassificationsMLCM 2002/02523
The Physical Object
Pagination135 p. :
Number of Pages135
ID Numbers
Open LibraryOL477103M
ISBN 109074538290
LC Control Number98202751

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  Niosomes, exhibiting a similar behavior to liposomes, are the vesicles that are made up of nonionic surfactants (e.g. alkyl ethers and alkyl esters) and cholesterol. These structures are stable on their own and they increase the stability of the encapsulated drugs. No special conditions are needed for handling and storage of these by:   Liposome Technology, Volume I: Liposome Preparation and Related Techniques, Third Edition, is a thoroughly updated and expanded new edition of a classic text in the field. Including step-by-step technical details, Volume I illustrates numerous methods for liposome preparation and auxiliary techniques necessary for the stabilization and characterizaReviews: 1. Offers a logically organized survey of vesicular science and the practical applications of vesicles - including the advances in drug delivery. This work contains over helpful citations, more than drawings and photographs, many in color, and some equations. This is a comprehensive review on the use of phospholipid nanovesicles for dermal/transdermal and nasal drug administration. Phospholipid-based vesicular carriers have been widely investigated for enhanced drug delivery via dermal/transdermal routes. Classic phospholipid vesicles, liposomes, do not penetrate the deep layers of the skin, but remain confined to the upper stratum corneum.

By March 9, PubMed had lis articles on liposomes. The liposome story began with a paper in , published in the Journal of Molecular Biology, in which Bangham and Horne showed electron microscopic images of multilamellar phospholipid vesicles. By , Bangham and his co‐workers had done the crucial experiments and in twin. Liposomes are phospholipid vesicles for targeting the drugs to the specific site of the body (Soni et al., ; Ganeshpurkar et al., ). They provide controlled and selective drug delivery and enhanced BA; therefore, they may be a potential candidate for the drug delivery via ocular route and suitable for both lipophilic and hydrophilic. ABOUT AUTHORS BHANDARI SALONI *, KISHNANI KHUSHBOO, RATHORE KAMAL SINGH BN College of Pharmacy, Udaipur-Raj. [email protected] ABSTRACT Liposomes are concentric bilayer vesicles, which were first developed by Bangham and his colleagues in They are highly efficient having high drug entrapment capacity. Due to their size, hydrophobic and .   Liposomes 1. LIPOSOMES AS A DRUG DELIVERY SYSTEM PREPARED BY: K. ARSHAD AHMED KHAN , (Ph.D) Dept. of Pharmaceutics RIPER. 2. INTRODUCTION • Liposomes are simple microscopic vesicles in which an aqueous volume is entirely enclosed by a membrane composed of lipid molecule.

The interaction of mixtures of sodium dodecyl sulfate (SDS) and oxyethylenated nonylphenol (30 mol of ethylene oxide) [NP(EO)30] with phosphatidylcholine liposomes was investigated. Permeability alterations were detected as a change in 5(6)-carboxyfluorescein (CF) released from the interior of vesicles, and bilayer solubilization was measured as a decrease in the static light scattered by. simplified membrane models of PC liposomes, P A liposomes and PC and P A mixed vesicles have been investigated in this work. The above surfactant was chosen because of its known irri-tating action on biological surfaces []. We have characterized in detail the vesicle to micelle structural transitions involved in the in-. Being a critical parameter that determines the fate of liposome and its distribution, we studied different factors affecting the particle size of liposomes including different phospholipid (Phosal ® 53 MCT) and cholesterol concentrations and the use of different types of non-ionic surfactants at fixed Phosal ® 53 MCT concentration of 50 mg. The properties of liposomes (charge density, membrane fluidity, and permeability) are determined by the lipid composition and size of the vesicle. The desired properties will be, in turn, determined by the use of the particular liposome. The vesicles offer wonderful, simple models to study the biochemistry and biophysics of natural membranes.